U.S. Cleanroom Cleaning Products Market Size, Share & Trends Analysis Report, By Product (Cleaning Chemicals, Supplies & Accessories), By End Use (Pharmaceutical & BioTechnology, Medical Device Manufacturing), And Segment Forecasts, 2025 - 2030

Market Size & Trends

The U.S. cleanroom cleaning products market size was estimated at USD 1,555.0 million in 2024 and is expected to expand at a CAGR of 6.5% from 2025 to 2030. This growth is driven primarily by the increasing demand from the pharmaceutical, biotechnology, and medical device manufacturing sectors. Cleanrooms require rigorous cleaning protocols to maintain sterile conditions, and this has significantly boosted the demand for specialized cleaning chemicals, consumables, and accessories.

The U.S. pharmaceutical and biotechnology industries are witnessing significant capacity expansions, particularly in biologics, gene therapies, and vaccine production. Facilities manufacturing these advanced therapies are held to cGMP (current Good Manufacturing Practices) and FDA standards, necessitating the frequent use of ISO-classified cleanrooms. Cleaning products-such as sterile wipes, disinfectants, and mopping systems compliant with USP <797> and USP <800>-are essential for maintaining microbial control. For instance, Moderna’s mRNA vaccine facilities and Pfizer’s gene therapy production lines employ multi-tiered cleanroom cleaning protocols that require validated and residue-free cleaning agents.

The CHIPS and Science Act (2022) has catalyzed domestic investment in semiconductor manufacturing, leading to the development of new fabs by companies such as Intel, TSMC, and Micron in Arizona, Ohio, and Texas. Semiconductor fabs operate at ISO Class 1-5 levels, where even submicron particles can impair production yields. This necessitates the use of highly specialized cleanroom mops, tacky mats, isopropyl alcohol-based agents, and lint-free wipes that are non-shedding and silicon-free.

The tightening of regulatory standards by agencies such as the U.S. Food and Drug Administration (FDA) and the International Organization for Standardization (ISO) requires rigorous contamination control measures in cleanroom operations. ISO 14644-1 Cleanrooms and Associated Controlled Environments Part 1 defines cleanliness according to levels from ISO Class 1 to ISO Class 9, about how ISO cleanroom cleanliness standards apply. The clean room class is the level of cleanliness the room complies with, according to the quantity and size of particles per cubic meter of air. Similarly, the Food and Drug Administration (FDA) sets stringent standards for cleanroom cleaning through Current Good Manufacturing Practices (cGMP) to ensure the purity and safety of pharmaceutical products. It expects the manufacturers to maintain Standard Operating Procedures (SOPs) detailing cleaning processes for all equipment and surfaces.

Compliance with these standards compels companies to invest in high-quality, validated cleaning products that support aseptic manufacturing practices. The growth of advanced manufacturing technologies, such as those used in semiconductor fabrication and nanotechnology, is fueling demand for ultra-clean environments, further favoring demand for specialized cleanroom cleaning products.

The rise in modular and flexible cleanroom designs, which are often used in temporary or rapidly expanding facilities such as pharmaceutical and biotechnology due to their speed of construction, adaptability, and scalability. These modular systems increase the demand for versatile, easy-to-integrate cleaning products that support various cleanroom classes and configurations. As industries continue to evolve and emphasize contamination control, the U.S. cleanroom cleaning products market is expected to see sustained growth, innovation, and diversification in product offerings. Contec's notable recent innovation is the QuicKlean™ Mopping System, tailored for compounding pharmacies and cleanroom environments. This system features disposable microfiber mop covers that are laundered for cleanliness and are compatible with a wide range of disinfectants. The QuicKlean system is designed for use in ISO Class 7 and 8 environments, offering low-lint construction and excellent cleaning efficiency for both wet and dry applications.

Product Insights

Cleaning chemicals accounted for a share of 59.4% of the overall U.S. cleanroom cleaning products industry in 2024. The demand for cleaning chemicals in the U.S. cleanroom cleaning products market is increasing due to the rising need for strict contamination control across critical industries such as pharmaceuticals, biotechnology, and medical device manufacturing. As these sectors grow, fueled by innovations in drug development, biologics, and personalized medicine, the standards for cleanliness and sterility have become more stringent. Regulatory agencies such as the FDA and ISO require validated cleaning protocols, which heavily rely on specialized chemicals such as disinfectants, sporicides, and alcohol-based solutions.

Demand for supplies & accessories in the U.S. cleanroom cleaning products market is expected to grow at a CAGR of 7.0% from 2025 to 2030. There is an increasing demand for efficient, disposable, and user-friendly solutions that enhance operational hygiene and reduce contamination risks. As cleanroom facilities expand, particularly in the pharmaceutical, biotech, and semiconductor sectors, there is a growing preference for pre-validated consumables like sterile wipes, gloves, gowns, mops, and sticky mats. These items are essential for maintaining cleanroom protocols without cross-contamination, especially in high-throughput environments.

End Use Insights

Pharmaceutical & BioTechnology accounted for a share of 34.5% of the overall U.S. cleanroom cleaning products industry in 2024. Rapid advancements in drug development, biologics cell, and gene therapies require highly controlled, sterile manufacturing environments. As these industries continue to grow, driven by an aging population, rising chronic diseases, and heightened global health awareness, companies are expanding production capacities and building new cleanroom facilities to meet regulatory standards and ensure product safety.

Demand for Semiconductors and Microelectronics manufacturing in the U.S. cleanroom cleaning products market is expected to grow at a CAGR of 7.7% from 2025 to 2030. As semiconductor technology evolves due to the increasing demand for smaller, more advanced, and high-performance electronic devices, the complexity and miniaturization of chips require even stricter control of cleanroom environments to prevent contamination, which can cause defects in microelectronic components. With the growing reliance on semiconductors across industries such as automotive, consumer electronics, and telecommunications, there is a heightened need for advanced cleanroom technologies and consumables. Includes specialized cleaning chemicals, wipes, gloves, and other accessories designed to meet the stringent cleanliness requirements of semiconductor fabrication.

Suppliers & Accessories in the U.S. cleanroom cleaning products industry are set to grow at a CAGR of 7.0% from 2025 to 2030. The increasing demand for highly controlled, contamination-free environments essential for advanced chip manufacturing requires cleanroom supplies such as particle-free wipes, antistatic gloves, gowns, and sticky mats. These ultrasensitive environments, where even microscopic contamination can compromise production yields, require these supplies. The trend toward more compact and powerful microchips also heightens the need for stricter cleanliness standards, accelerating the adoption of precision-designed consumables that ensure product quality and process reliability.

Key U.S. Cleanroom Cleaning Products Company Insights

The U.S. cleanroom cleaning products market is concentrated primarily due to the presence of several globally recognized players as well as regional players. Some prominent companies in the U.S. cleanroom cleaning products industry are Kimberly-Clark Corporation, Ecolab Life Sciences, 3M, Clean Air Technology, Inc., Mecart, Abtech Inc., and others.

• Kimberly-Clark Corporation is a multinational company that manufactures and sells consumer and professional products, with a focus on paper-based products. They are known for brands like Kleenex, Huggies, Cottonelle, and Scott. Kimberly-Clark Professional offers a variety of products specifically designed for cleanroom cleaning and contamination control, including wipes, gloves, apparel, and hand hygiene solutions.

• Ecolab Life Sciences is a division of Ecolab, a global leader in water, hygiene, and energy technologies. It focuses on providing cleaning, sanitation, and contamination control solutions for pharmaceutical and personal care manufacturers. Ecolab Life Sciences offers a wide range of solutions, including cleaning and disinfection chemistry, equipment, and Bioquell vaporized hydrogen peroxide decontamination. They work with customers in pharmaceutical, cleanroom, and personal care manufacturing to optimize production performance, mitigate risks, and ensure business continuity.

Recent Developments

• In March 2025, Kimberly-Clark Professional introduced Onvation® SmartFit™ technology, a compact, internet-enabled sensor designed to fit inside paper towels and bath tissue dispensers. This innovation provides real-time data to help commercial facility managers schedule janitorial staff more efficiently, reduce waste, and improve the guest experience. The sensor tracks product levels and restroom traffic, offering predictive data-based insights to eliminate guesswork from restroom servicing.

• In January 2025, 3M reported higher-than-expected fourth-quarter profits due to increased demand for industrial adhesives, tapes, and electronics. The company projected 2025 adjusted profits in alignment with Wall Street estimates, focusing on a cost-cutting restructuring initiative and high-margin products. Notably, 3M announced plans to spin off its healthcare division, Solventum Corporation, as part of its strategic restructuring. The company also emphasized new product development, contributing to a 32% increase in product launches.

U.S. Cleanroom Cleaning Products Market Report Scope

U.S. Cleanroom Cleaning Products Market Report Segmentation

This report forecasts revenue growth at the country level and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2018 to 2030. For the purpose of this study, Grand View Research has segmented the U.S. cleanroom cleaning products market based on product and end use:

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Cleaning Chemicals

  • Supplies & Accessories

    • Wipes

    • Mops & Sleeves

      • Disposable

      • Reusable

    • Trolleys/Bucket Systems

    • Bucket, Boxes, & Trays

    • Gloves & Safety Kit

    • Matting

    • Others (Reusable wipes, Waste bins, Brooms & brushes, Scrubbing pad, Spill pads, Swabs, etc.)

• End Use Outlook (Revenue, USD Million, 2018 - 2030)

  • Pharmaceutical & BioTechnology

  • Medical Device Manufacturing

  • Semiconductor and Microelectronics Manufacturing

  • Aerospace Industry

  • Others (Optics & Photonics, Disk Drive Manufacturing, Automotive Industry, Nanotech R&D, etc.)